Search results for " Uric acid"

showing 10 items of 31 documents

Hyperuricemia and Risk of Cardiovascular Outcomes: The Experience of the URRAH (Uric Acid Right for Heart Health) Project

2020

The latest European Guidelines of Arterial Hypertension have officially introduced uric acid evaluation among the cardiovascular risk factors that should be evaluated in order to stratify patient's risk. In fact, it has been extensively evaluated and demonstrated to be an independent predictor not only of all-cause and cardiovascular mortality, but also of myocardial infraction, stroke and heart failure. Despite the large number of studies on this topic, an important open question that still need to be answered is the identification of a cardiovascular uric acid cut-off value. The actual hyperuricemia cut-off (> 6 mg/dL in women and 7 mg/dL in men) is principally based on the saturation …

0301 basic medicineMaleTime FactorsDiseaseUric acid.chemistry.chemical_compound0302 clinical medicineRisk FactorsUric Acid Cardiovascular events epidemiologyEpidemiologyMulticenter Studies as TopicHyperuricemiaStrokeCardiovascular events; Cardiovascular mortality; Uric acid; URRAHMiddle AgedPrognosisObservational Studies as TopicItalyCardiovascular DiseasesResearch DesignFemaleCardiology and Cardiovascular MedicineAdultmedicine.medical_specialtyCardiovascular mortalityUric acid · Cardiovascular mortality · Cardiovascular events · URRAHContext (language use)Cardiovascular eventHyperuricemiaRisk AssessmentCardiovascular events03 medical and health sciencesURRAHcardiovascular events; cardiovascular mortality; urrah; uric acidPharmacotherapyInternal medicineInternal MedicinemedicineHumansAgedRetrospective Studiesbusiness.industrymedicine.disease030104 developmental biologychemistryHeart failureUric acidbusinessUric acid030217 neurology & neurosurgeryCardiovascular events; Cardiovascular mortality; Uric acid; URRAH; Adult; Aged; Biomarkers; Cardiovascular Diseases; Female; Humans; Hyperuricemia; Italy; Male; Middle Aged; Multicenter Studies as Topic; Observational Studies as Topic; Prognosis; Research Design; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Uric AcidBiomarkers
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Serum uric acid and fatal myocardial infarction: Detection of prognostic cut-off values: The URRAH (Uric Acid Right for Heart Health) study

2019

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AdultMalemedicine.medical_specialtyAdolescentPhysiologycut-off value030204 cardiovascular system & hematology03 medical and health scienceschemistry.chemical_compoundYoung Adult0302 clinical medicineuric acidInternal medicineInternal MedicinemedicineORIGINAL PAPERS: EpidemiologyHumanssex030212 general & internal medicineHyperuricemiaMyocardial infarctionRisk factorAgedAged 80 and overuric acid cardiovascular arterial hypertensioncut-off value mortality myocardial infarctionsex uric acidProportional hazards modelbusiness.industrycut-off value mortality myocardial infarction sex uric acidHazard ratioMiddle Agedmedicine.diseasePrognosismortalityConfidence intervalUric acid myocardial infarction epidemiologymyocardial infarctionchemistryItalyHypertensionComputingMethodologies_DOCUMENTANDTEXTPROCESSINGcut-off value; mortality; myocardial infarction; sex; uric acidUric acidFemaleCardiology and Cardiovascular MedicinebusinessCohort study
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Absence of an independent association between serum uric acid and left ventricular mass in Caucasian hypertensive women and men

2013

Background and aim: Experimentally uric acid may induce cardiomyocyte growth and interstitial fibrosis of the heart. However, clinical studies exploring the relationship between serum uric acid (SUA) and left ventricular (LV) mass yielded conflicting results. The aim of our study was to evaluate the relationships between SUA and LV mass in a large group of Caucasian essential hypertensive subjects. Methods and results: We enrolled 534 hypertensive patients free of cardiovascular complications and without severe renal insufficiency. In all subjects routine blood chemistry, including SUA determination, echocardiographic examination and 24 h ambulatory blood pressure (BP) monitoring were obtai…

AdultMalemedicine.medical_specialtyAmbulatory blood pressureEndocrinology Diabetes and MetabolismHeart VentriclesPopulationLeft ventricular maMedicine (miscellaneous)Blood PressureLeft ventricular hypertrophyEssential hypertensionWhite PeopleEssential hypertensionBody Mass Indexchemistry.chemical_compoundSerum uric acidInternal medicinemedicineHumansEssential hypertension; Serum uric acid; Cardiovascular risk; Left ventricular mass; Left ventricular hypertrophyeducationeducation.field_of_studyCreatinineNutrition and Dieteticsbusiness.industryLeft ventricular hypertrophyBlood Pressure Monitoring AmbulatoryMiddle Agedmedicine.diseaseCardiovascular riskUric AcidEndocrinologyBlood pressureCross-Sectional StudieschemistryBlood chemistryEchocardiographyCreatinineHypertensionCardiologyFemaleCardiology and Cardiovascular MedicinebusinessBody mass index
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Relationships between mild hyperuricaemia and aortic stiffness in untreated hypertensive patients.

2013

Background and aims: Clinical studies exploring the relationship between serum uric acid (SUA) and arterial stiffness yielded conflicting results. Only in a few of these studies, arterial distensibility was examined by measuring aortic pulse wave velocity (PWV), which is considered the gold standard for evaluating arterial stiffness. In none of the previous investigations was the influence of SUA on aortic distensibility assessed, taking into account the effect of albuminuria. The purpose of our study was to comprehensively analyse the relationships between SUA and aortic PWV in a group of essential hypertensive patients. Methods and results: We enrolled 222 untreated and uncomplicated hype…

AdultMalemedicine.medical_specialtySettore MED/09 - Medicina InternaEndocrinology Diabetes and MetabolismMedicine (miscellaneous)HyperuricemiaArteriosclerosiPulse Wave AnalysisEssential hypertensionEssential hypertensionBody Mass IndexSerum uric acidVascular StiffnessRisk FactorsStatistical significanceInternal medicinemedicineAlbuminuriaHumansPulse wave velocityAortaTriglyceridesSettore MED/14 - NefrologiaMetabolic SyndromeUnivariate analysisNutrition and Dieteticsbusiness.industryArteriosclerosisMiddle Agedmedicine.diseaseSettore MED/11 - Malattie Dell'Apparato CardiovascolareUric AcidPulse wave velocityEndocrinologyAortic stiffneCross-Sectional StudiesHypertensioncardiovascular systemArterial stiffnessAlbuminuriaCardiologyAortic stiffnessFemalemedicine.symptomCardiology and Cardiovascular MedicinebusinessNutrition, metabolism, and cardiovascular diseases : NMCD
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Relationship between aortic stiffness and serum uric acid in essential hypertension

2012

In last years hyperuricemia has been associated with an increased incidence of renal and cardiovascular events in general population, as well as in patients with diabetes and hypertension. However, the role of serum uric acid (SUA) as independent cardiovascular risk factor is still controversial. It is well known that increased aortic stiffness is a powerful independent predictor of cardiovascular events. Little is known about the influence of uric acid on aortic distensibility in subjects with arterial hypertension. The aim of our study was to evaluate the relationships between SUA and aortic stiffness in a group of essential hypertensive patients, attending our Hypertension Centre. We enr…

Aortic stiffness serum uric acid essential hypertension
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Relationships between diuretic related hyperuricemia and cardiovascular events: data from the URRAH (URic acid Right for heArt Health) study.

2021

Objective Although the relationship between hyperuricemia and cardiovascular events has been extensively examined, data on the role of diuretic-related hyperuricemia are still scanty. The present study was designed to collect information on the relationship between diuretic-related hyperuricemia and cardiovascular events. Methods The URic acid Right for heArt Health (URRAH) study is a nationwide, multicentre, observational cohort study involving data on individuals recruited from all the Italy territory under the patronage of the Italian Society of Hypertension with an average follow-up period of 122.3 ± 66.9 months. Patients were classified into four groups according to the diuretic use (y…

Cardiovascular eventMalemedicine.medical_specialtySettore MED/09 - Medicina InternaPhysiologymedicine.medical_treatmentdiureticRenal functionHyperuricemiaCardiovascular eventcardiovascular events; cardiovascular mortality; diuretic; uric acid030204 cardiovascular system & hematology03 medical and health scienceschemistry.chemical_compoundcardiovascular events0302 clinical medicineuric acidRisk Factorscardiovascular mortalityInternal medicineInternal MedicinemedicineHumans030212 general & internal medicineHyperuricemiaDiureticsHeart healthUric acid cardiovascular events diuretics epidemiologycardiovascular events cardiovascular mortality diuretic uric acidbusiness.industrySerum uric acidMiddle Agedmedicine.diseasechemistryHypertensionUric acidDiureticCardiology and Cardiovascular MedicinebusinessCohort study
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Serum uric acid levels threshold for mortality in diabetic individuals: The URic acid Right for heArt Health (URRAH) project

2022

Background and aim: The URRAH (URic acid Right for heArt Health) Study has identified cut-off values of serum uric acid (SUA) predictive of total mortality at 4.7 mg/dl, and cardiovascular (CV) mortality at 5.6 mg/dl. Our aim was to validate these SUA thresholds in people with diabetes. Methods and results: The URRAH subpopulation of people with diabetes was studied. All-cause and CV deaths were evaluated at the end of follow-up. A total of 2570 diabetic subjects were studied. During a median follow-up of 107 months, 744 deaths occurred. In the multivariate Cox regression analyses adjusted for several confounders, subjects with SUA ≥5.6 mg/dl had higher risk of total (HR: 1.23, 95%CI: 1.04-…

Diabetes mellituNutrition and DieteticsSettore MED/09 - Medicina InternaCardiovascular mortalitySerum uric acid Cardiovascular mortality All-cause mortality Diabetes mellitus Hyperuricemia Diagnostic thresholdsEndocrinology Diabetes and MetabolismMedicine (miscellaneous)HyperuricemiaAll-cause mortalityUric AcidDiagnostic thresholdsall-cause mortality; cardiovascular mortality; diabetes mellitus; diagnostic thresholds; hyperuricemia; serum uric acid; humans; risk factors; uric acid; diabetes mellitus; hyperuricemiaDiagnostic thresholdDiabetes mellitusSerum uric acidRisk FactorsAll-cause mortality; Cardiovascular mortality; Diabetes mellitus; Diagnostic thresholds; Hyperuricemia; Serum uric acidHumansCardiology and Cardiovascular Medicine
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No independent association of serum uric acid with left ventricular mass in hypertensive patients

2010

Left ventricular maArterial Hypertension.Serum Uric Acid
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Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population a…

2019

The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly participants with overweight/obesity and metabolic syndrome in the (Prevencion con Dieta Mediterranea) PREDIMED-Plus trial. Accelerometry-derived sleep duration and sleep variability were measured. Linear regression models were fitted to examine the aforementioned associations. A 1 hour/night increment in sleep duration was inversely associated with SUA concentrations ( = -0.07, p = 0.047). Further adjustment for leukocytes attenuated this association (p = 0.050). Each …

Male0301 basic medicinesueñoNefrología y urologíahumanosserum uric acid to creatinine ratioOverweightchemistry.chemical_compound0302 clinical medicineRisk FactorsMedicinemediana edadancianoeducation.field_of_studyNutrition and DieteticsMediterranean RegionCommunicationácido úricoMiddle AgedcreatininaSleep in non-human animals3. Good healthCardiovascular DiseasesCreatinineObesitatFemalemedicine.symptomlcsh:Nutrition. Foods and food supplymedicine.medical_specialtyserum uric acidPopulationenfermedades cardiovascularesDietética y nutriciónlcsh:TX341-641Cardiología03 medical and health sciences:Ciencias de la Salud::Medicina preventiva [Materias Investigacion]Internal medicineHumansfactores de riesgoObesityeducationAgedCreatininebusiness.industryActigraphymedicine.diseaseObesityactigraphy serum uric acid serum uric acid to creatinine ratio sleep durationSonUric AcidÀcid úricCross-Sectional Studies030104 developmental biologyEndocrinologychemistrySpainUric acidsleep durationMetabolic syndromebusinessSleepUric acidBiomarkers030217 neurology & neurosurgeryestudios transversalesFood Scienceactigraphy
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Gout, allopurinol intake and clinical outcomes in the hospitalized multimorbid elderly.

2014

Background: Increased serum uric acid has been considered a cardiovascular risk factor but no study has assessed its relation with hospital mortality or length of stay. On the basis of data obtained from a prospective registry, the prevalence of gout/hyperuricemia and its association with these and other clinical parameters was evaluated in an Italian cohort of elderly patients acutely admitted to internal medicine or geriatric wards. Methods: While the prevalence of gout was calculated by counting patients with this diagnosis hyperuricemia was inferred in patients taking allopurinol at hospital admission or discharge, on the assumption that this drug was only prescribed owing to the findin…

MaleKidney DiseaseSettore MED/09 - Medicina InternahyperuricemiaComorbiditieschemistry.chemical_compoundCardiovascular Diseasegout elderlyAllopurinol; Comorbidities; Elderly; Gout; Hyperuricemia; Outcomes; Age Factors; Aged; Aged 80 and over; Allopurinol; Cardiovascular Diseases; Chronic Disease; Comorbidity; Female; Gout; Hospital Mortality; Hospitalization; Humans; Hyperuricemia; Kidney Diseases; Length of Stay; Male; Treatment Outcome; Uric Acid; Internal Medicine; Medicine (all)80 and overMedicineAge FactorHyperuricemiaHospital MortalityOutcomeAged 80 and overOUTCOMESMedicine (all)Age FactorsHospitalizationcomorbidityTreatment OutcomeCardiovascular DiseasesAllopurinol; Comorbidities; Elderly; Gout; Hyperuricemia; OutcomesCohortFemaleKidney DiseasesComorbiditieAllopurinol; Comorbidities; Elderly; Gout; Hyperuricemia; Outcomes; Age Factors; Aged; Aged 80 and over; Allopurinol; Cardiovascular Diseases; Chronic Disease; Comorbidity; Female; Gout; Hospital Mortality; Hospitalization; Humans; Hyperuricemia; Kidney Diseases; Length of Stay; Male; Treatment Outcome; Uric AcidHumanmedicine.drugmusculoskeletal diseasesmedicine.medical_specialtycongenital hereditary and neonatal diseases and abnormalitiesAllopurinolAllopurinol; Comorbidities; Elderly; Gout; Hyperuricemia; Outcomes; Age Factors; Aged; Aged 80 and over; Allopurinol; Cardiovascular Diseases; Chronic Disease; Comorbidity; Female; Gout; Hospital Mortality; Hospitalization; Humans; Hyperuricemia; Kidney Diseases; Length of Stay; Male; Treatment Outcome; Uric Acid; Internal MedicineallopurinolNOgoutGout allopurinol hyperuricemia comorbidities outcomes elderlyInternal medicineInternal MedicineHumansRisk factorIntensive care medicineAdverse effectAgedELDERLYgout allopurinol hyperuricemia comorbidities outcomes elderlybusiness.industrynutritional and metabolic diseasesLength of Staymedicine.diseaseComorbidityGoutUric AcidchemistryChronic DiseaseUric acidbusiness
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